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Sandra L Hofmann Selected Research

palmitoyl-protein thioesterase

1/2018Cross-Linked Enzyme Aggregates as Versatile Tool for Enzyme Delivery: Application to Polymeric Nanoparticles.
9/2012Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis.
4/2004pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.
6/2002The effects of lysosomotropic agents on normal and INCL cells provide further evidence for the lysosomal nature of palmitoyl-protein thioesterase function.

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Sandra L Hofmann Research Topics

Disease

15Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
10/2015 - 06/2002
1Gaucher Disease (Gaucher's Disease)
01/2018
1Glycogen Storage Disease Type II (Pompe's Disease)
01/2018
1Globoid Cell Leukodystrophy (Krabbe Disease)
01/2018
1Thrombosis (Thrombus)
12/2016
1Ischemic Stroke
12/2016
1Hemorrhage
12/2016
1Carotid Stenosis (Carotid Artery Stenosis)
12/2016
1Hemoglobin SC Disease (Disease, Hemoglobin SC)
01/2016
1Lysosomal Storage Diseases (Lysosomal Storage Disease)
09/2015
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2015
1Neoplasms (Cancer)
04/2015
1Hypoxia (Hypoxemia)
11/2013
1Achlorhydria (Hypochlorhydria)
03/2011
1Disease Progression
11/2007
1Blindness (Hysterical Blindness)
11/2007
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2006
1Myoclonus (Nocturnal Myoclonus)
11/2005
1Seizures (Absence Seizure)
11/2005
1Intellectual Disability (Idiocy)
09/2003

Drug/Important Bio-Agent (IBA)

9EnzymesIBA
01/2018 - 08/2002
8Proteins (Proteins, Gene)FDA Link
09/2012 - 09/2003
4palmitoyl-protein thioesteraseIBA
01/2018 - 06/2002
2LipidsIBA
06/2005 - 04/2004
2HydrolasesIBA
04/2004 - 08/2002
2Fatty Acids (Saturated Fatty Acids)IBA
04/2004 - 09/2003
1beta-GlucosidaseIBA
01/2018
1GalactosylceramidaseIBA
01/2018
1alpha-Glucosidases (Acid Maltase)IBA
01/2018
1Clopidogrel (Plavix)FDA Link
12/2016
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
12/2016
1Factor VII (Proconvertin)IBA
12/2016
1Hemoglobins (Hemoglobin)IBA
01/2016
1Small Interfering RNA (siRNA)IBA
04/2015
1TransferasesIBA
04/2015
1Tetracycline (Achromycin)FDA LinkGeneric
04/2015
1Cyclosporine (Ciclosporin)FDA LinkGeneric
11/2013
1Adenosine (Adenocard)FDA LinkGeneric
11/2013
1StaurosporineIBA
11/2013
1Proton Pumps (Proton Pump)IBA
03/2011
1CeroidIBA
10/2006
1lipopigmentsIBA
10/2006
1OligosaccharidesIBA
06/2005

Therapy/Procedure

4Enzyme Replacement Therapy
01/2018 - 04/2010
2Therapeutics
12/2016 - 11/2007
1Splenectomy
01/2016
1Investigational Therapies (Experimental Therapy)
10/2015
1Traction
09/2015